\u0645\u0627\u0647\u0631 \u0628\u062f\u0631 <\/p>\n
\u0639\u0644\u0627\u062c \u0641\u0645\u0648\u064a \u0645\u0648\u0635\u0648\u0641 \u064a\u0633\u062a\u062e\u062f\u0645 \u0645\u0639 \u0641\u0648\u0644\u0641\u064a\u0633\u062a\u0631\u0627\u0646\u062a \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0624\u0647\u0644\u064a\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0645\u062a\u0642\u062f\u0645<\/p>\n
\u062e\u0637\u0648\u0629 \u062c\u062f\u064a\u062f\u0629 \u062a\u062f\u0639\u0645 \u062a\u0648\u0633\u064a\u0639 \u0627\u0644\u062e\u064a\u0627\u0631\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0633\u0648\u0642 \u0627\u0644\u0645\u0635\u0631\u064a\u060c \u0648\u062a\u0633\u0644\u064a\u0637 \u0627\u0644\u0636\u0648\u0621 \u0639\u0644\u0649 \u0623\u0647\u0645\u064a\u0629 \u062a\u0639\u0632\u064a\u0632 \u0627\u0644\u0648\u0639\u064a \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0645\u062a\u0642\u062f\u0645. <\/p>\n
\u0623\u0639\u0644\u0646\u062a \u0634\u0631\u0643\u0629 \u0623\u0633\u062a\u0631\u0627\u0632\u064a\u0646\u064a\u0643\u0627 \u0645\u0635\u0631 \u0639\u0646 \u0625\u062a\u0627\u062d\u0629 \u0639\u0642\u0627\u0631 (\u062f\u0648\u0627\u0621 \u0643\u0627\u0628\u064a\u0641\u0627 \u0633\u064a\u0631\u062a\u064a\u0628 Capivasertib) \u0641\u064a \u0627\u0644\u0633\u0648\u0642 \u0627\u0644\u0645\u0635\u0631\u064a \u0648 \u0647\u0648 \u062f\u0648\u0627\u0621 \u0645\u0648\u0635\u0648\u0641 \u064a\u0633\u062a\u062e\u062f\u0645 \u0628\u0627\u0644\u0627\u0634\u062a\u0631\u0627\u0643 \u0645\u0639 )\u0641\u0648\u0644\u0641\u064a\u0633\u062a\u0631\u0627\u0646\u062a<\/p>\n
(fulvestrant \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0645\u0648\u0636\u0639\u064a \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0623\u0648 \u0627\u0644\u0646\u0642\u064a\u0644\u064a ( \u0627\u0644\u0645\u0646\u062a\u0634\u0631) \u0627\u0644\u0625\u064a\u062c\u0627\u0628\u064a \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 (ER-positive) \u0648\u0627\u0644\u0633\u0644\u0628\u064a \u0644\u0640 (HER2 (HER2-negative \u0648\u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0648\u0627\u062d\u062f \u0623\u0648 \u0623\u0643\u062b\u0631 \u0645\u0646 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0641\u064a PIKBCA \/ AKT1 \/ TEN \u060c \u0648\u0630\u0644\u0643 \u0628\u0639\u062f \u062d\u062f\u0648\u062b \u0627\u0646\u062a\u0643\u0627\u0633\u0629 \u0623\u0648 \u062a\u0642\u062f\u0645 \u0644\u0644\u0645\u0631\u0636 \u0623\u062b\u0646\u0627\u0621 \u0623\u0648 \u0628\u0639\u062f \u0646\u0638\u0627\u0645 \u0639\u0644\u0627\u062c\u064a \u0642\u0627\u0626\u0645 \u0639\u0644\u0649 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a\u060c \u0643\u062e\u064a\u0627\u0631 \u0639\u0644\u0627\u062c\u064a \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 \u0641\u064a \u062e\u0637\u0648\u0629 \u062a\u0639\u0643\u0633 \u0623\u0647\u0645\u064a\u0629 \u062a\u0648\u0641\u064a\u0631 \u062e\u064a\u0627\u0631\u0627\u062a \u0639\u0644\u0627\u062c\u064a\u0629 \u062d\u062f\u064a\u062b\u0629 \u062f\u0627\u062e\u0644 \u0645\u0635\u0631 \u0628\u0645\u0627 \u064a\u062f\u0639\u0645 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u064a\u0633\u0647\u0645 \u0641\u064a \u062a\u0639\u0632\u064a\u0632 \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0635\u062d\u064a\u0629 \u0627\u0644\u0645\u062a\u0637\u0648\u0631\u0629.<\/p>\n
\u064a\u0623\u062a\u064a \u0647\u0630\u0627 \u0627\u0644\u0625\u0639\u0644\u0627\u0646 \u0641\u064a \u0648\u0642\u062a \u0644\u0627 \u064a\u0632\u0627\u0644 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u064a\u062a\u0635\u062f\u0631 \u0642\u0627\u0626\u0645\u0629 \u0623\u0643\u062b\u0631 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0646\u062a\u0634\u0627\u0631\u064b\u0627 \u0628\u064a\u0646 \u0627\u0644\u0646\u0633\u0627\u0621 \u0639\u0627\u0644\u0645\u064a\u064b\u0627 \u0648\u0641\u064a \u0645\u0635\u0631 \u0628\u0634\u0643\u0644 \u062e\u0627\u0635\u060c \u0645\u0627 \u064a\u0624\u0643\u062f \u0636\u0631\u0648\u0631\u0629 \u062a\u0633\u0644\u064a\u0637 \u0627\u0644\u0636\u0648\u0621 \u0639\u0644\u0649 \u0623\u0647\u0645\u064a\u0629 \u0631\u0641\u0639 \u0627\u0644\u0648\u0639\u064a \u0628\u0627\u0644\u0645\u0631\u0636\u060c \u0648\u062a\u0639\u0632\u064a\u0632 \u062b\u0642\u0627\u0641\u0629 \u0627\u0644\u0643\u0634\u0641 \u0627\u0644\u0645\u0628\u0643\u0631 \u0648\u0627\u0644\u0645\u062a\u0627\u0628\u0639\u0629 \u0627\u0644\u0637\u0628\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0645\u0631\u0629\u060c \u0625\u0644\u0649 \u062c\u0627\u0646\u0628 \u0623\u0647\u0645\u064a\u0629 \u0625\u062a\u0627\u062d\u0629 \u062e\u064a\u0627\u0631\u0627\u062a \u0639\u0644\u0627\u062c\u064a\u0629 \u0645\u062a\u0646\u0648\u0639\u0629 \u0644\u0644\u0645\u0631\u0636\u0649. \u0648\u064a\u0633\u062a\u062e\u062f\u0645 \u0644\u0645\u0631\u064a\u0636\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u0649 \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0627\u0644\u0644\u0648\u0627\u062a\u064a \u0644\u062f\u064a\u0647\u0646 \u0648\u0627\u062d\u062f \u0623\u0648 \u0623\u0643\u062b\u0631 \u0645\u0646 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0641\u064a PIK3CA \/ AKT1 PTEN \/ \u0648\u0647\u064a \u0637\u0641\u0631\u0627\u062a \u0634\u0627\u0626\u0639\u0629 \u062a\u064f\u0635\u064a\u0628 \u0646\u062d\u0648 %\u0666\u0660% \u0645\u0646 \u062d\u0627\u0644\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0625\u064a\u062c\u0627\u0628\u064a \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0648\u0627\u0644\u0633\u0644\u0628\u064a.<\/p>\n
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